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| Catalog Code: | NB100-87002 |
| Product Name: | PRKAR2A Antibody |
| Product Description: | Rabbit Polyclonal anti-PKA-RIIalpha |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 5576 |
| Reference Sequence: | NP_004148.1 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 50 and 100 of human protein kinase, cAMP-dependent, regulatory, type II, alpha using the numbering given in entry NP_004148.1 (GeneID 5576). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for western blot and immunoprecipitation. |
| Background: | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq] |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | Western Blot 1:2000-1:10000, immunoprecipitation 2-5 mcg/mg lysate |
| Species Summary: | Hu |
| Alternate Names: | anti-RKAR2A antibody, anti-PKA-RIIalpha antibody, anti-protein kinase antibody, anti-cAMP-dependent antibody, anti-regulatory antibody, anti-type II antibody, anti-alpha antibody, anti-PKR2 antibody, anti-regulatory subunit alpha 2 antibody |
| Package Size: | 0.02 mg |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |