| request information: |
|
| Catalog Code: | NB100-869 |
| Product Name: | CBL Antibody |
| Product Description: | Goat Polyclonal anti-CBL |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 867 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide with sequence REFVSISSPAHVAT, representing the C Terminus of the protein (residues 893-906) according to NP_005179. |
| Cross Reactivity: | Cross-reacts with Mouse. Expected to cross-react with Human and Rat due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used in Western Blot where a 120kDa band is seen in 3T3 lysate. Recommended Starting Dilutions*:WB: 1.0-3.0ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL?s interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | Western Blot |
| Species Summary: | Mu |
| Alternate Names: | anti-C-CBL antibody, anti-CBL2 antibody, anti-RNF55 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Langdon WY et al. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci U S A 86:1168-72 (1989). |
order or
more information: | company product webpage |