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| Catalog Code: | NB100-868 |
| Product Name: | COX2 Antibody |
| Product Description: | Goat Polyclonal anti-COX2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 5743 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide with sequence NPTVLLKERSTEL, representing the C terminus of the human protein (residues 592-604) according to NP_000954. |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Cow, Horse, Pig and Sheep due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used in Western Blot where a 72 kDa band is seen (predicted molecular weight: 69 kDa). Not tested in other applications.Recommended Starting Dilutions*:WB: 0.5-2 ug/ml*Optimal dilutions should be determined by the end user. |
| Localization: | Microsomal membrane |
| Background: | COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Cyclooxygenase-2 antibody, anti-COX 2 antibody, anti-PGG/HS antibody, anti-PGH synthase 2 antibody, anti-PGHS2 antibody, anti-PHS II antibody, anti-Prostaglandin endoperoxide synthase 2 antibody, anti-Prostaglandin G/H synthase 2 precursor antibody, anti-Prostaglandin G/H synthase and cyclooxygenase antibody, anti-Prostaglandin G/H synthase antibody, anti-Prostaglandin H2 synthase 2 antibody, anti-PTGS2 antibody, anti-TIS10 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Ballif BA, Mincek NV, Barratt JT, Wilson ML, Simmons DL.Interaction of cyclooxygenases with an apoptosis- and autoimmunity associated protein.Proc Natl Acad Sci U S A. 1996 May 28;93(11):5544-9. PMID: 8643612 |
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more information: | company product webpage |