| CatalogCode: | NB100-862 |
| ProductName: | PACSIN3 Antibody |
| Product Description: | Goat Polyclonal anti-PACSIN3 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide with sequence APEEDAGGEALGGS, representing the N terminus of the human protein (residues 2-15) according to NP_057307. |
| CrossReactivity: | Cross-reacts with Human. Expected to cross-react with Mouse (92% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used in Peptide ELISA and Western Blot where a 50 kDa is seen in H460 and human heart and muscle lysates (predicted MW of 49kDa according to NP_057307). Not tested in other applications. Recommended Starting Dilutions*:ELISA: 1/16000WB: 1-3 ug/ml*Optimal dilutions should be determined by the end user. |
| Localization: | Cytoplasmic. Detected at the inner aspect of the plasma membrane in cells or myotubes. |
| Background: | PACSIN 3 differs from the other family members in having a short proline-rich region and lacking asparagine-proline-phenylalanine motifs. In contrast to the neurospecific PACSIN 1 and the ubiquitously expressed PACSIN 2, PACSIN 3 is mainly detected in lung and muscle tissues. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| ALTnames: | anti-Endophilin 1 antibody, anti-Endophilin I antibody, anti-Protein kinase C and casein kinase substrate in neurons 3 antibody, anti-SH3 domain containing protein 6511 antibody |
| ProteinTarget: | PACSIN3 antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | Modregger J et al. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci 113 Pt 24:4511-21 (2000). Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M.PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.Gene. 2001 Jan 10;262(1-2):199-205. PMID: 11179684 |
| Gene_Id: | 29763 |
| Omim_ID: | NB100-57392 |