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| Catalog Code: | NB100-852 |
| Product Name: | ATF4 Antibody |
| Product Description: | Goat Polyclonal anti-ATF4 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 468 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide with sequence EEVRKARGKKRVP, representing the C-Terminus of the human protein (residues 339-351) according to NP_001666. |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Rat and Mouse due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used in Western Blot where a 40kDa band is seen in Raji cell lysate. Recommended Starting Dilutions*:Western Blot: 1-3 ug/ml*Optimal dilutions shoudl be determined by the end user. |
| Background: | ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Activating Transcription Factor 4 antibody, anti-CREB2 antibody, anti-Cyclic AMP dependent transcription factor ATF 4 antibody, anti-Cyclic AMP response element binding protein 2 antibody, anti-DNA binding protein TAXREB67 antibody, anti-Tax Responsive Enhancer Element B67 antibody, anti-TAXREB67 antibody, anti-TXREB antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Tsujimoto A et al. Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol 65:1420-6 (1991). |
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