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| Catalog Code: | NB100-82244 |
| Product Name: | Tau Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-Tau [Ser404] |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | P10636 |
| Immunogen: | The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 404 (D-T-SP-P-R). |
| Specificity: | Tau (specific to Phospho-Ser404) antibody detects endogenous levels of Tau only when phosphorylated at serine404. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:Western Blot |
| Background: | Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | Western Blot, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-DDPAC antibody, anti-Disinhibition Dementia Parkinsonism Amyotrophy Complex antibody, anti-FLJ31424 antibody, anti-FTDP 17 antibody, anti-FTDP17 antibody, anti-G Protein Beta 1 Gamma 2 Subunit Interacting Factor 1 antibody, anti-MAPT antibody, anti-MAPTL antibody, anti-MGC138549 antibody, anti-Microtubule Associated Protein Tau antibody, anti-MSTD antibody, anti-MTAPT antibody, anti-MTBT 1 antibody, anti-MTBT 2 antibody, anti-MTBT1 antibody, anti-MTBT2 antibody, anti-Neurofibrillary Tangle Protein antibody, anti-Paired Helical Filament Tau antibody, anti-PHF Tau antibody, anti-PPND antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| Phosphorylated: | Ser404 |
| Notes Main: | MAPK, Neuroscience |
| General References: | Li G, Yin H, et.al .(2004) J Biol Chem ; 279(16): 15938-45. Noble W, et al. (2003) Neuron ; 38(4): 555-65. Giasson BI, et al.(2002).. Biochemistry; 41(51): 15376-87. Lee G., et.al. (1989). Neuron 2:1615-1624. Andreadis A.,et.al. (1992) Biochemistry 31:10626-10633. Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimers Disease using Tau (phospho-Ser404) antibody (#11112). Western blot analysis of extract from mouse brain tissue using Tau (Ab-404) antibody (#21101, Lane 1 and 2) and Tau(phospho-Ser404) antibody (#11112, Lane 3 and 4). For Research Use Only |
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