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| Catalog Code: | NB100-82196 |
| Product Name: | Smad1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Smad1 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | Q15797 |
| Immunogen: | The antiserum was produced against synthesized non-phosphopeptide derived from human Smad1 around the phosphorylation site of serine 465 (I-S-S-V-SP). |
| Specificity: | Smad1 (specific to a.a. 465) antibody detects endogenous levels of total Smad1 protein. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:Western Blot 1:500-1:1000 |
| Background: | Smad proteins have been implicated as downstream effectors of TGF beta/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF beta and activin mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGF beta signaling by interfering with TGF beta mediated phosphorylation of other Smad family members. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | Western Blot 1:500-1:1000, |
| Species Summary: | Hu, Mu, Rt |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Sodium Azide |
| Notes Main: | TGF-beta signaling |
| General References: | Hiroaki Seto, et al. (2004) J Clin Invest. March 1; 113(5): 718726 Linyu Li, et al. (2004) Mol Cell Biol. January; 24(2): 856864. Claire Nourry, et al. (2004) BMC Cell Biol. 5: 20 |
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