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| Catalog Code: | NB100-82131 |
| Product Name: | PAK1/PAK2/PAK3 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-PAK1/PAK2/PAK3 [Thr423/Thr402/Thr421] |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | Q13153//Q13177//O75914 |
| Immunogen: | The antiserum was produced against synthesized phosphopeptide derived from human PAK1 around the phosphorylation site of threonine 423 (R-S-TP-M-V). |
| Specificity: | PAK1/PAK2/PAK3 (specific to Phospho-Thr423/Thr402/Thr421) antibody detects endogenous levels of PAK1/PAK2/PAK3 only when phosphorylated at threonine 423/402/421. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:immunohistochemistry 1:50-1:100 |
| Background: | In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | immunohistochemistry 1:50-1:100, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-Alpha PAK antibody, anti-AlphaPAK antibody, anti-Beta PAK antibody, anti-BetaPAK antibody, anti-bPAK antibody, anti-Gamma PAK antibody, anti-GammaPAK antibody, anti-hPAK 3 antibody, anti-hPAK3 antibody, anti-MGC130000 antibody, anti-MGC130001 antibody, anti-MRX 30 antibody, anti-MRX 47 antibody, anti-MRX30 antibody, anti-MRX47 antibody, anti-Oligophrenin 3 antibody, anti-Oligophrenin3 antibody, anti-OPHN 3 antibody, anti-OPHN3 antibody, anti-OTTHUMP00000062894 antibody, anti-p21 (CDKN1A) activated kinase 2 antibody, anti-p21 (CDKN1A) activated kinase 3 antibody, anti-p21 activated kinase 1 + 2 + 3 antibody, anti-p21 activated kinase 1 antibody, anti-p21 activated kinase 2 antibody, anti-p21 activated kinase 3 antibody, anti-p21/Cdc42/Rac1 activated kinase 1 antibody, anti-P65 PAK antibody, anti-P65PAK antibody, anti-PAK 1 antibody, anti-PAK 2 antibody, anti-PAK 3 antibody, anti-PAK 65 antibody, anti-PAK alpha antibody, anti-PAK gamma antibody, anti-PAK1 antibody, anti-PAK2 antibody, anti-PAK3 antibody, anti-PAK3 beta antibody, anti-PAK3beta antibody, anti-PAK65 antibody, anti-PAKalpha antibody, anti-PAKgamma antibody, anti-S6/H4 kinase antibody, anti-Serine/threonine protein kinase PAK 1 antibody, anti-Serine/threonine protein kinase PAK 2 antibody, anti-Serine/threonine protein kinase PAK 3 antibody, anti-Serine/threonine protein kinase PAK1 antibody, anti-Serine/threonine protein kinase PAK2 antibody, anti-Serine/threonine protein kinase PAK3 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| Phosphorylated: | Thr423/Thr402/Thr421 |
| Notes Main: | Cytoskeletal/Adhesion, Cancer/Apoptosis, MAPK, Kinase/Phosphatases |
| General References: | Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695. Jung JH, et al. (2005) J Biol Chem; 280:40025-40031. Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189 Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447. |
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