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| Catalog Code: | NB100-82009 |
| Product Name: | JNK 1 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-JNK 1 [Thr183] |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | P45984; P53779 |
| Immunogen: | The antiserum was produced against synthesized phosphopeptide derived from human JNK2/3/SAPK around the phosphorylation site of threonine 183 (M-M-TP-P-Y). |
| Specificity: | SAPK/JNK (specific to Phospho-Thr183) antibody detects endogenous levels of SAPK/JNK only when phosphorylated at threonine 183. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:immunohistochemistry 1:50-1:100 |
| Background: | JNK1(MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | immunohistochemistry 1:50-1:100, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-c Jun N terminal kinase 1 antibody, anti-JAK 1A antibody, anti-JAK1A antibody, anti-JNK 1 antibody, anti-JNK 46 antibody, anti-JNK antibody, anti-JNK1 alpha 2 antibody, anti-JNK1A2 antibody, anti-JNK21B1/2 antibody, anti-Kinase JNK1 antibody, anti-MAPK 8 antibody, anti-MAPK8 antibody, anti-Mitogen activated protein kinase 8 antibody, anti-MK08 antibody, anti-p54 gamma antibody, anti-PRKM 8 antibody, anti-PRKM8 antibody, anti-Protein kinase JNK1 antibody, anti-SAPK 1 antibody, anti-SAPK gamma antibody, anti-SAPK1 antibody, anti-Stress activated protein kinase JNK1 antibody, anti-Tyrosine protein kinase JAK1 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| Phosphorylated: | Thr183 |
| Notes Main: | MAPK, Kinase/Phosphatases |
| General References: | I. Ferrer, et al. (2003) Neuropathology & Applied Neurobiology 29: 23 Zhonghong Guan, et al. (1999) J Biol Chem, Vol. 274: 36200-36206 D.Margriet Ouwens, et al. (2002)The EMBO Journal 21: 37823793, S Matsuyoshi, et al. (2006) British Journal of Cancer 94: 532 |
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