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| Catalog Code: | NB100-81876 |
| Product Name: | Dab1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Dab1 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | O75553 |
| Immunogen: | The antiserum was produced against synthesized non-phosphopeptide derived from human Dab1around the phosphorylation site of tyrosine 232 (G-V-YP-D-V). |
| Specificity: | Dab1 (specific to a.a. 232) antibody detects endogenous levels of total Dab1 protein. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:immunohistochemistry 1:50-1:100 |
| Background: | Disruption of Dab1 results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | immunohistochemistry 1:50-1:100, |
| Species Summary: | Hu, Mu, Rt |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Sodium Azide |
| Notes Main: | Neuroscience, Adaptors |
| General References: | Kelian Chen, et,al. (2003) J. Cell Sci ; 117: 4527 - 4536. Vera Strasser, et,al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386. Izhar Ben-Shlomo, et,al. (2003) Sci. STKE ; 2003: 9. H. M. Kim, et,al. (2002) PNAS ; 99: 4020. |
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