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| Catalog Code: | NB100-81853 |
| Product Name: | c-Jun Antibody |
| Product Description: | Rabbit Polyclonal anti-c-Jun |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Reference Sequence: | P05412 |
| Immunogen: | The antiserum was produced against synthesized non-phosphopeptide derived from human c-Jun around the phosphorylation site of serine 63 (L-T-SP-P-D). |
| Specificity: | c-Jun (specific to a.a. 63) antibody detects endogenous levels of c-Jun protein around serine 63. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for:Western Blot |
| Background: | The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
| Application Summary: | Western Blot, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-Activator Protein 1 antibody, anti-AP 1 antibody, anti-AP1 antibody, anti-Enhancer Binding Protein AP1 antibody, anti-Jun Activation Domain Binding Protein antibody, anti-JUN antibody, anti-Jun oncogene antibody, anti-JUN protein antibody, anti-JUNC antibody, anti-p39 antibody, anti-Proto oncogene cJun antibody, anti-Transcription Factor AP1 antibody, anti-V jun avian sarcoma virus 17 oncogene homolog antibody, anti-vJun Avian Sarcoma Virus 17 Oncogene Homolog antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Sodium Azide |
| Notes Main: | MAPK, Chromatin/Transcription |
| General References: | Wei W, et al. (2005). Cancer Cell. 8(1): 25-33. Sevilla A, et al. (2004). Oncogene.23 (55): 8950-8958. Li L, et al. (2004). J Biol Chem.279 (6): 4058-4065. Hurd C, et al. (2002). Oncogene.21 (14): 2154-2160. |
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