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| Catalog Code: | NB100-81683 |
| Product Name: | NUMA Antibody |
| Product Description: | Rabbit Polyclonal anti-NUMA |
| Clonality: | Polyclonal |
| ListPrice: | 375 |
| Gene ID: | 4926 |
| Reference Sequence: | NP_006176.2 |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 900 and 950 of human nuclear mitotic apparatus protein 1 using the numbering given in entry NP_006176.2 (GeneID 4926). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry on paraffin sections. Epitope exposure with citrate bufferexposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated. |
| Background: | The nuclear mitotic apparatus protein (NuMA) is a critical component of the mitotic spindle that is responsible for organizing minus-ends of microtubules at spindle poles. NUMA is regulated by phosphorylation and associates with dynein and dynactin in its phosphorylated form. Dephosphorylation of NUMA in anaphase results in the release from dynein and dynactin to allow spindle disassembly. NUMA, in association with dynein and dynactin, also interacts with 4.1R in a complex of spindle pole organizing proteins. Other NUMA interacting proteins include GAS41, tankyrase, and Rae1. These interactions indicate a broader role for NUMA function in the nucleus. Alternate names for NUMA include SP-H antigen and NUMA1. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | Immunohistochemistry-Paraffin 1:100-1:500 |
| Species Summary: | Hu |
| Alternate Names: | anti-UMA antibody, anti-NUMA1 antibody, anti-NUMA-1 antibody, anti-nuclear mitotic apparatus protein 1 antibody, anti-SP-H Antigen antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% Sodium Azide |
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