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| Catalog Code: | NB100-81043 |
| Product Name: | KCNQ2 Antibody |
| Product Description: | Rabbit Polyclonal anti-KCNQ2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide derived from N-terminal domain of KCNQ2 protein |
| Specificity: | Antiserum reacts specifically with human 95 kDa protein |
| Cross Reactivity: | Cross reacts with KCNQ2 from mouse, rat proteins and other species |
| Packaging: | 0.2 ml Whole Rabbit Ascites |
| Uses: | Optimal dilution should be determined by the end userThe following are guidelines only :- Immunohistochemistry : 1/100 to 1/1 000- Western Blot : 1/500 to 1/5 000 |
| Background: | KCNQs are members of the voltage dependent non inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1 to 5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M current. Inhibition of M current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry 1:100-1:1000, Western Blot 1:500-1:5000 |
| Species Summary: | Mu, Rt(-) |
| Package Size: | 0.2 ml |
| Preservative: | No Preservative |
| Notes Main: | Lyophilized powder (glass vial) - Vial must be reconstituted in 0.2 ml of distilled water |
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