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| Catalog Code: | NB100-81031 |
| Product Name: | HCN2 Antibody |
| Product Description: | Rabbit Polyclonal anti-HCN2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide derived from C-terminal domain of HCN2 protein |
| Specificity: | Antiserum reacts specifically with human 97 kDa protein |
| Cross Reactivity: | Cross reacts with HCN2 protein from mouse, rat and other species |
| Packaging: | 0.2 ml Whole Rabbit Ascites |
| Uses: | Optimal dilution should be determined by the end userThe following are guidelines only :- Immunohistochemistry : 1/200 to 1/1 000- Western Blot : 1/500 to 1/5 000 |
| Background: | Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry 1:200-1:1000, Western Blot 1:500-1:5000 |
| Species Summary: | Mu, Rt(-) |
| Package Size: | 0.2 ml |
| Preservative: | No Preservative |
| Notes Main: | Lyophilized powder (glass vial) - Vial must be reconstituted in 0.2 ml of distillated water |
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