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| Catalog Code: | NB100-80911 |
| Product Name: | Retinoblastoma 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Retinoblastoma 1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | RB1 |
| Reference Sequence: | P06400 |
| Immunogen: | Recombinant protein; Recombinant (partial), N-terminal |
| Cross Reactivity: | This antibody is reactive against Human, Mouse |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera |
| Uses: | This antibody is useful for IHC 1:100, WB, IF |
| Background: | Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Phosphate-buffered solution, pH 7.2, and 50% glycerol |
| Application Summary: | immunohistochemistry 1:100, Western Blot, immunoflourescence, |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-RB1 antibody, anti-OSRC antibody, anti-P105-RB antibody, anti-PP110 antibody, anti-RB antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.09% sodium azide |
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