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| Catalog Code: | NB100-809 |
| Product Name: | Integrin linked Kinase Antibody |
| Product Description: | Goat Polyclonal anti-Integrin linked Kinase |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 3611 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide: DMIVPILEKMQDK (Human) (C terminal). |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Mouse, Rat and Guinea pig due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Western Blot: Use at a concentration of 0.5 - 2 ug/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 52 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-ILK antibody, anti-integrin-linked kinase antibody, anti-P59 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature. 1996 Jan 4;379(6560):91-6. PMID: 8538749 |
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