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| Catalog Code: | NB100-80886 |
| Product Name: | eIF2 Alpha Antibody |
| Product Description: | Rabbit Polyclonal anti-eIF2 Alpha |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | EIF2A |
| Immunogen: | Synthetic peptide; Amino acids surrounding Ser 51 of human EIF2A |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera |
| Uses: | This antibody is useful for IHC 10 ug/ml, WB 1:500 1:1000 |
| Background: | eIF2 alpha is a 36 kDa protein which is ubiquitously expressed in many cell types. The eIF2 protein, which is composed of three subunits (alpha, beta and gamma), is one of the key molecules in the initiation of translation. In mammalian cells, eIF2 alpha is phosphorylated at serine 51 (human EIF2 alpha, the equivalent residue in mouse is serine 52) by at least two kinases: the haem-controlled repressor (HCR) and the interferon inducible double stranded RNA-dependent protein kinase (PKR). Phosphorylation of eIF2 alpha blocks the GDP-GTP exchange activity of eIF2 beta, resulting in the suppression of protein synthesis. The phosphorylation of eIF2 alpha is an important regulatory process in protein synthesis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS, 50% glycerol |
| Application Summary: | immunohistochemistry 10 ug/ml, Western Blot 1:500-1:1000, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-EIF2A antibody, anti-CDA02 antibody, anti-EIF-2A antibody, anti-MST089 antibody, anti-MSTP004 antibody, anti-MSTP089 antibody, anti-Eukaryotic Translation Initiation Factor 2A antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% sodium azide |
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more information: | company product webpage |
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