| request information: |
|
| Catalog Code: | NB100-80873 |
| Product Name: | PARK7/DJ-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-PARK7/DJ-1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | PARK7 |
| Reference Sequence: | Q99497 |
| Immunogen: | Synthetic peptide; aa 177-189 of Human PARK7 protein. |
| Cross Reactivity: | This antibody is reactive against Chicken, Dog, Fish, Frog, Human, Mouse, Rat |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera |
| Uses: | This antibody is useful for IHC 2.5 ug/ml, WB 1:500 1:2000, ELISA 1:10000 1:50000 |
| Background: | PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Application Summary: | immunohistochemistry 2.5 ug/ml, Western Blot 1:500-1:2000, ELISA 1:10000-1:50000, |
| Species Summary: | Ch, Ca, Fi, Am, Hu, Mu, Rt |
| Alternate Names: | anti-PARK7 antibody, anti-DJ-1 antibody, anti-DJ1 antibody, anti-FLJ27376 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.01% Sodium Azide |
order or
more information: | company product webpage |
|