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| Catalog Code: | NB100-80856 |
| Product Name: | Tuberous Sclerosis 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Tuberous Sclerosis 2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | TSC2 |
| Reference Sequence: | P49815 |
| Immunogen: | Synthetic peptide; 15 amino acid peptide from near the carboxy-terminus of human TSC2 |
| Cross Reactivity: | This antibody is reactive against Human, Mouse |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera |
| Uses: | This antibody is useful for IHC 5 ug/ml, WB 1 ug/ml 1 ug/ml |
| Background: | Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| Application Summary: | immunohistochemistry 5 ug/ml, Western Blot 1-1 ug/ml, |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-TSC2 antibody, anti-FLJ43106 antibody, anti-LAM antibody, anti-TSC4 antibody, anti-TUBERIN antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% sodium azide |
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more information: | company product webpage |