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| Catalog Code: | NB100-80850 |
| Product Name: | TOLLIP Antibody |
| Product Description: | Rabbit Polyclonal anti-TOLLIP |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | TOLLIP |
| Reference Sequence: | Q9H0E2 |
| Immunogen: | Synthetic peptide; 16 amino acid peptide from near the center of human TOLLIP |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Rabbit antisera |
| Uses: | This antibody is useful for ICC, IHC 5 ug/ml, WB 0.5 ug/ml 2 ug/ml |
| Background: | Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. |
| Storage: | Store at 4C. Do not freeze. |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| Application Summary: | Immunocytochemistry, immunohistochemistry 5 ug/ml, Western Blot 0.5-2 ug/ml, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-TOLLIP antibody, anti-FLJ33531 antibody, anti-IL-1RACPIP antibody, anti-Toll Interacting Protein antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% sodium azide |
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