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| Catalog Code: | NB100-80838 |
| Product Name: | TIRAP Antibody |
| Product Description: | Rabbit Polyclonal anti-TIRAP |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | TIRAP |
| Reference Sequence: | P58753 |
| Immunogen: | Synthetic peptide; peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.05 mg Affinity purified Rabbit antisera |
| Uses: | This antibody is useful for IHC 2 ug/ml, WB 0.5 ug/ml 2 ug/ml |
| Background: | The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| Application Summary: | immunohistochemistry 2 ug/ml, Western Blot 0.5-2 ug/ml, |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-TIRAP antibody, anti-FLJ42305 antibody, anti-MAL antibody, anti-WYATT antibody, anti-Toll-interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% sodium azide |
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more information: | company product webpage |