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| Catalog Code: | NB100-80826 |
| Product Name: | Alpha-synuclein Antibody |
| Product Description: | Rabbit Polyclonal anti-Alpha-synuclein |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene Symbol: | SNCA |
| Reference Sequence: | P37840 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Synthetic peptide; Peptide near the C-terminus of human SNCA protein |
| Cross Reactivity: | This antibody is reactive against Human, Rat |
| Packaging: | 0.05 mg Rabbit antisera |
| Uses: | This antibody is useful for IHC 2.5 ug/ml, WB 1 ug/ml 2 ug/ml |
| Background: | Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. |
| Storage: | Store at 4C. Do not freeze. |
| Host Name: | Rabbit |
| Buffer: | PBS, pH 7.4, 0.2% BSA |
| Application Summary: | immunohistochemistry 2.5 ug/ml, Western Blot 1-2 ug/ml, |
| Species Summary: | Hu, Rt(-) |
| Alternate Names: | anti-SNCA antibody, anti-ALPHA-SYNUCLEIN antibody, anti-MGC110988 antibody, anti-NACP antibody, anti-PARK1 antibody, anti-PARK4 antibody, anti-PD1 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.05% sodium azide |
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