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| Catalog Code: | NB100-808 |
| Product Name: | CSK Antibody |
| Product Description: | Goat Polyclonal anti-CSK |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 1445 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide: EQLEHIKTHELHL (Human). |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Mouse and Rat due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Western Blot: Use at a concentration of 0.5 - 2 ug/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).
Immunohistochemsitry: In paraffin-embedded Human Tonsil, strong staining of germinal centre cells and less intense labelling in the interfollicular area. Recommended dilution of 0.1-0.3 ug/ml.
Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | C terminal Src kinase (CSK) is a non receptor protein tyrosine kinase. One of its major functions is to specifically phosphorylate a conserved C terminal tyrosine of Src family kinases thereby down regulating their kinase activity. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft associated protein PAG (CSK binding protein). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | immunohistochemistry -P, Western Blot , Immunohistochemistry-Paraffin 0.1ug/ml |
| Species Summary: | Hu |
| Alternate Names: | anti-C SRC antibody, anti-C src Tyrosine Kinase antibody, anti-Csk A antibody, anti-P60 Src antibody, anti-Protein tyrosine kinase CYL antibody, anti-Proto oncogene tyrosine protein kinase antibody, anti-Tyrosine protein kinase CSK antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Holtrich U et al. Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. Proc Natl Acad Sci U S A 88:10411-5 (1991). |
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