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| Catalog Code: | NB100-80055 |
| Product Name: | Synapsin I Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Synapsin I Phospho (EP2162Y) [Ser9] |
| Clone: | EP2162Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Reference Sequence: | P17600 |
| Immunogen: | A synthetic phospho-peptide corresponding to residues surrounding serine 9 of human synapsin I protein. |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding serine 9 of human synapsin I protein. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, Immunocytochemistry |
| Background: | Synapsin I is a member of neuron-specific phosphoproteins that associate with synaptic vesicles (1). Three mammalians synapsins have been identified, Synapsin I, II and III. Generated by differential splicing, Synapsin Ia and Synapsin Ib differ in their Carboxyl termini (2). Synapsin I also functions in binding synaptic vesicles to several elements of the cytoskeleton including actin filaments, microtubules and spectrin. (3) Fairly abundant protein of the brain (0.4%), Synapsin I is best known to be CaM kinase II substrate in addition to cAMP-dependent protein kinase. (4) Phosphorylation at site Ser 566 and Ser 603 by CaM kinase II will cause a 5 fold decrease in the affinity of synaptic vesicles binding. A phosphorylation of serine 9 on synapsin amino-terminal can lead to inhibition in its binding to phospholipids and dissociation of synapsins from synaptic vesicles. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:1000-5000, immunohistochemistry 1:250-500, Immunocytochemistry 1:50 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-Synapsin I antibody, Anti-Brain protein 4.1 antibody |
| Package Size: | 0.1 ml |
| Phosphorylated: | Ser9 |
| General References: | 1. Greengard P., et al. Science 259:780-785, 1993. 2. S-dhof TC., et al. Science 245:1474-1480, 1989 3. Bahler M, Greengard P, Nature 326:704-707, 1989. 4. Huttner WB., et al. J Biol Chem 256:1482-1488, 1989. 5. Schiebler, W, et al. J. Biol Chem. 261, 8383-8390, 1986. |
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