| request information: |
|
| Catalog Code: | NB100-80050 |
| Product Name: | SOD1 Antibody |
| Product Description: | Rabbit Polyclonal anti-SOD1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Reference Sequence: | P00441 |
| Immunogen: | A synthetic peptide corresponding to residues near the N-terminus of human SOD1 was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against Human |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, Immunocytochemistry, immunoprecipitation |
| Background: | The eukaryotic copper,zinc superoxide dismutases are remarkably stable dimeric proteins that maintain an intrasubunit disulfide bond in the reducing environment of the cytosol and are active under a variety of stringent denaturing conditions. The structural interplay of conserved disulfide bond and metal-site occupancy in human copper,zinc superoxide dismutase (SOD1) is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (1). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). A crystal structure of human SOD, along with two other SOD structures, established that all 12 observed FALS mutant sites alter conserved interactions critical to the beta-barrel fold and dimer contact, rather than catalysis (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:5000, immunohistochemistry 1:50-100, Immunocytochemistry 1:50-100, immunoprecipitation 1:20 |
| Species Summary: | Hu |
| Package Size: | 0.1 ml |
| Preservative: | 0.25% Sodium Azide |
| General References: | 1. Arnesano F, et al. J Biol Chem 279(46):47998-8003, 2004 2. Deng HX, et al. Science 261(5124):1047-51, 1993. |
order or
more information: | company product webpage |