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| Catalog Code: | NB100-80025 |
| Product Name: | PKC delta Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-PKC delta Phospho (EPR1485Y) [Thr507] |
| Clone: | EPR1485Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Reference Sequence: | Q05655 |
| Immunogen: | A phospho-specific peptide corresponding to residues surrounding Threonine 507 of human PKC delta was used as an immunogen. This antibody detects PKC delta phosphorylated at T507. |
| Specificity: | A phospho-specific peptide corresponding to residues surrounding Threonine 507 of human PKC delta was used as an immunogen. This antibody detects PKC delta phosphorylated at T507. |
| Cross Reactivity: | This antibody is reactive against Human |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot |
| Background: | PKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:500 |
| Species Summary: | Hu |
| Alternate Names: | Anti-nPKC-delta antibody |
| Package Size: | 0.1 ml |
| Phosphorylated: | Thr507 |
| General References: | 1. Nomoto S, et al. Genes Cells 2(10):601-14, 1997 2. Yoshida K, et al. EMBO J 22(6):1431-41, 2003 3. Mecklenbrauker I, et al. Nature 431(7007), 2004 |
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