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| Catalog Code: | NB100-80005 |
| Product Name: | Na+/K+ ATPase alpha Antibody |
| Product Description: | Rabbit Monoclonal anti-Na+/K+ ATPase alpha (EP1845Y) |
| Clone: | EP1845Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Reference Sequence: | P05023 |
| Immunogen: | A synthetic peptide corresponding to residues near the N-terminus of human Na+/K+ ATPase ? was used as an immungen. |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human Na+/K+ ATPase ? was used as an immungen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, flow cytometry / FACS analysis |
| Background: | Na+, K+-ATPase is a heterodimeric enzyme responsible for the active maintenance of sodium and potassium gradients across the plasma membrane (1). The sodium- and potassium-dependent adenosine triphosphatase (Na+,K(+)-ATPase) maintains the transmembrane Na+ gradient to which is coupled all active cellular transport systems (2). It is well accepted that inhibition of the Na,K-ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentration and strengthens cardiac contraction. Assessing the phenotypes of mouse hearts with genetically reduced levels of Na,K-ATPase alpha 1 or alpha 2 isoforms clearly demonstrates different functional roles for these isoforms in vivo. Results definitively illustrate a specific role for the alpha 2 Na,K-ATPase isoform in Ca2+ signaling during cardiac contraction (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:10000-20000, immunohistochemistry 1:100-250, flow cytometry / FACS analysis 1:20 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-Sodium pump subunit alpha-1 antibody, Anti-Na(+)/K(+) ATPase alpha-1 subunit antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Yang-Feng TL, et al. Genomics 2(2):128-38, 1988 2. Herrera VL, et al. Science 249(4972):1023-6, 1990 3. James PF, et al. Mol Cell 3(5):555-63, 1999. |
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