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| Catalog Code: | NB100-79998 |
| Product Name: | MKP-3 Antibody |
| Product Description: | Rabbit Monoclonal anti-MKP-3 (EPR129Y) |
| Clone: | EPR129Y |
| Clonality: | Monoclonal |
| ListPrice: | 335 |
| Reference Sequence: | Q16828 |
| Immunogen: | A synthetic peptide corresponding to residues near the C-terminus of human MKP-3 was used as an immunogen. |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human MKP-3 was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, flow cytometry / FACS analysis, immunoprecipitation |
| Background: | MKP-3 is expressed constitutively in human skin fibroblasts and dephosphorylates and inactivates MAP kinase in vitro and in vivo. MKP-3 displays very low activity towards the stress-activated protein kinases (SAPKs) or RK/p38 in vitro, indicating that these kinases are not physiological substrates for MKP-3. MKP-3 is thought to play a role in the dephosphorylation and inactivation of MAP kinases and are therefore likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. For this reason it has been suggested that MAP kinase phosphatases may be tumor suppressors (1). MKP-3 is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis. In situ hybridization studies of MKP-3 in brain reveal enrichment within the CA1, CA3, and CA4 layers of the hippocampus. Observations indicate that MKP-3 is a novel dual-specificity phosphatase that displays a distinct tissue distribution, subcellular localization, and regulated expression, suggesting a unique function in controlling MAP kinase family members (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:500, immunohistochemistry 1:50-100, immunoprecipitation 1:40, flow cytometry / FACS analysis 1:60 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-Mitogen-activated protein kinase phosphatase 3 antibody, Anti-MAP kinase phosphatase 3 antibody, Anti-MKP-3 antibody, Anti-Dual specificity protein phosphatase PYST1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% Sodium Azide |
| General References: | 1. Groom LA, et al. EMBO J, 15(14):3621 - 3632, 1996 2. Smith A, et al. Genomics 42(3):524-7, 1997 |
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