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| Catalog Code: | NB100-79997 |
| Product Name: | MIP1 alpha Antibody |
| Product Description: | Rabbit Monoclonal anti-MIP1 alpha (EP493Y) |
| Clone: | EP493Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Reference Sequence: | P10147 |
| Immunogen: | A synthetic peptide corresponding to residues in the C-terminus of human MIP 1 alpha was used as an immunogen. |
| Epitope: | (C-Term) |
| Cross Reactivity: | This antibody is reactive against Human |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot |
| Background: | Macrophage inflammatory protein-1 alpha (MIP-1 alpha) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 alpha is involved in the acute inflammatory state, in the recruitment and activation of polymorphonuclear leukocytes and can inhibit infection of cells with human immunodeficiency virus type 1 (HIV-1) (2). MIP-1 alpha also acts as a potent growth, survival, and chemotactic factor in multiple melanoma cells. Two know isoforms of MIP-1 alpha can be found; LD78 alpha and LD78 beta (3). Depending on the isoform or its N-terminal processing, one or more of the CC chemokine receptors CCR1, CCR2, CCR3 and CCR5 can recognize MIP alpha, thus inhibiting HIV infection (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:5000 |
| Species Summary: | Hu |
| Alternate Names: | Anti-CCL3 antibody, Anti-Macrophage inflammatory protein 1-alpha antibody, Anti-MIP-1-alpha antibody, Anti-Tonsillar lymphocyte LD78 alpha protein antibody, Anti-G0/G1 switch regulatory protein 19-1 antibody, Anti-G0S19-1 protein antibody, Anti-SIS-beta antibody, Anti-PAT 464.1 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Jenne, D.; Stanley, K. K. EMBO J. 4: 3153-3157, 1985. 2. S.D. Wolpe, et al., J. Exp. Med. 167 (1988), pp. 570-581. 3. D.R. Forsdycke Biochem. Biophys. Res. Commun. 28 (1985), pp. 619-625. 4. Patricia Menten, Anja Wuyts and Jo Van Damme. Cytokine & Growth Factor Reviews 13,(2002) 455-481 |
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