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| Catalog Code: | NB100-79977 |
| Product Name: | IL-3R Beta Antibody |
| Product Description: | Rabbit Polyclonal anti-IL-3R Beta |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Reference Sequence: | P32927 |
| Immunogen: | A synthetic peptide corresponding to residues in C-terminus of human IL-3R ß was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry |
| Background: | Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:5000, immunohistochemistry 1:100-250 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-GM-CSF/IL-3/IL-5 receptor common beta-chain antibody, Anti-CD131 antigen antibody, Anti-CDw131 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Stomski FC, et al. Mol Cell Bio 16:3035-3046, 1996. 2. Hayashida K, et al. Proc Natl Acad Sci USA 87:9655, 1990 3. Dirksen U, et al. J Clin Invest 100:2211-2217, 1997. 4. Weiss M, et al. Blood 82:3298, 1993 |
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