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| Catalog Code: | NB100-79965 |
| Product Name: | HER4 / c-ErbB4 Antibody |
| Product Description: | Rabbit Monoclonal anti-HER4 / c-ErbB4 (EP192Y) |
| Clone: | EP192Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Reference Sequence: | Q15303 |
| Immunogen: | A synthetic peptide near the C-terminus (cytoplasmic domain) of human Her4/ErbB4 was used as immunogen. |
| Specificity: | A synthetic peptide near the C-terminus (cytoplasmic domain) of human Her4/ErbB4 was used as immunogen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot |
| Background: | HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:1000-2000 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-p180erbB4 antibody, Anti-Tyrosine kinase-type cell surface receptor HER4 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Plowman, G.D., et al. Proc Natl Acad Sci U S A. 90: 1746-50 (1993). 2. Elenius, K., et al. J Biol Chem. 272: 26761-8 (1997). 3. Garcia, R.A., et al. Proc Natl Acad Sci U S A. 97: 3596-601 (2000). |
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