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| Catalog Code: | NB100-79951 |
| Product Name: | GABA(B) R2 Antibody |
| Product Description: | Rabbit Monoclonal anti-GABA(B) R2 (EP2411Y) |
| Clone: | EP2411Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Reference Sequence: | Q75899 |
| Immunogen: | A synthetic peptide corresponding to residues near the C-terminus of human GABA(B) R2 was used as an immunogen. |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human GABA(B) R2 was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, Immunocytochemistry, flow cytometry / FACS analysis |
| Background: | GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic (GABA(A/C)) receptors to produce fast synaptic inhibition and metabotropic (GABA(B)) receptors to produce slow, prolonged inhibitory signals. Results indicate that, in vivo, functional brain GABA(B) receptors may be heterodimers composed of GABA(B)R1 and GABA(B)R2 (1). Identification of a functional homomeric GABABR2 coupled to adenylyl cyclase suggests that the complexity of GABAB pharmacological data is at least in part due to the presence of more than one receptor and opens avenues for future research leading to an understanding of metabotropic GABA receptor signal transduction mechanisms (2). The activity of GABA(B) R2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:500, immunohistochemistry 1:100-250, Immunocytochemistry 1:50-100, flow cytometry / FACS analysis 1:40 |
| Species Summary: | Hu, Mu, Rt |
| Package Size: | 0.1 ml |
| General References: | 1. White JH, et al. Nature 396(6712): 679-82, 1998 2. Martin SC et al. Mol Cell Neurosci 13(3):180-91, 1999 3. Ng GY, et al. J Biol Chem 274(12):7607-10, 1999 |
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