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| Catalog Code: | NB100-79931 |
| Product Name: | DARPP-32 Antibody |
| Product Description: | Rabbit Monoclonal anti-DARPP-32 (EP720Y) |
| Clone: | EP720Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Reference Sequence: | Q9UD71 |
| Immunogen: | A synthetic peptide corresponding to residues near the N-term of human DARPP-32 was used as immunogen. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Rabbit ascites |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, Immunocytochemistry, immunoprecipitation |
| Background: | The 32kDa dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) can either function as a serine/threonine kinase or as a serine/threonine phosphatase depending upon which particular amino acid residue is phosphorylated (1). When phosphorylated by protein kinase A (PKA) at threonine 34, DARPP-32 becomes a potent inhibitor of protein phosphatase-1 (2-3). Alternatively, when phosphorylated at threonine 75 by cyclin-dependent kinase 5(Cdk5), DARPP-32 is converted into an inhibitor of PKA (1). DARPP-32 and truncated DARPP (t-DARPP) are overexpressed in gastric cancers (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:5000-50000, immunohistochemistry 1:250-500, Immunocytochemistry 1:50-100, immunoprecipitation 1:50 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-Dopamine- and cAMP-regulated neuronal phosphoprotein antibody, Anti-DARPP-32 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Bibb et al. Nature 402: 669-671, 1999. 2. Greengard, P.; Allen, P. B.; Nairn, A. C. : Neuron 23: 435-447, 1999. 3. Hemmings, H. C., Jr.; Greengard, P.; Tung, H. Y.; Cohen, P. : Nature 310: 503-505, 1984. 4. El-Rifai, W.; Smith, M. F., Jr.; Li, G.; Beckler, A.; Carl, V. S.; Montgomery, E.; Knuutila, S.; Moskaluk, C. A.; Frierson, H. F., Jr.; Powell, S. M. :Cancer Res. 62: 4061-4064, 2002. |
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