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| Catalog Code: | NB100-79914 |
| Product Name: | Chromogranin A Antibody |
| Product Description: | Rabbit Polyclonal anti-Chromogranin A |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Reference Sequence: | P10645 |
| Immunogen: | A synthetic peptide corresponding to residues near the C-terminus of human Chromogranin A was used as an immunogen. |
| Epitope: | (C-term) |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, Rat |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera |
| Uses: | This antibody is useful for: Western Blot, immunohistochemistry, Immunocytochemistry |
| Background: | Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release (1). Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells (2). CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:50000, immunohistochemistry 1:100-200, Immunocytochemistry 1:50-100 |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | Anti-CgA antibody, Anti-Pituitary secretory protein I antibody, Anti-SP-I antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.25% sodium azide |
| General References: | 1. Hendy GN, et al. Clin Invest Med 18(1):47-65, 1995 2. Blois A, et al. Regul Pept 135(1-2):78-84, 2006 3. Leibovitch I, et al. Harefuah 145(1):25-9, 2006 |
| Novus References: | 1. de Jong EK, Vinet J, Stanulovic VS, et al. Expression, transport, and axonal sorting of neuronal CCL21 in large dense-core vesicles. FASEB J 2008:fj.07-101907. |
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