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| Catalog Code: | NB100-79870 |
| Product Name: | CCBL1 Antibody |
| Product Description: | Goat Polyclonal anti-CCBL1 |
| Clonality: | Polyclonal |
| ListPrice: | 195 |
| Gene ID: | 883 (human) |
| Gene Symbol: | CCBL1 |
| Reference Sequence: | NP_004050.3; NP_001116144.1 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide, C-DISDFKRKMPD, representing the internal region of the sequence according to NP_004050.3; NP_001116144.1 |
| Epitope: | DISDFKRKMPD |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Preliminary experiments in Human Brain (Cerebral and frontal cortex) and Human Breast cancer lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? |
| Background: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application. This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| Application Summary: | ELISA 1:32000 |
| Alternate Names: | anti-CBL1 antibody, anti-cysteine conjugate-beta lyase antibody, anti-glutamine transaminase K antibody, anti-kyneurenine aminotransferase antibody, anti-GTK antibody, anti-KATI antibody, anti-MGC29624 antibody, anti-cytoplasmic cysteine conjugate-beta lyase antibody, anti-glutamine-phenylpyruvate aminotransferase antibody, anti-kynurenine aminotransferase I antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Sodium Azide |
| Homology: | Human |
| Notes Main: | This antibody is expected to recognize both reported isoforms (NP_004050.3; NP_001116144.1) |
| General References: | Cooper AJ. The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. Neurochem Int. 2004 Jun;44(8):557-77. Review. Erratum in: Neurochem Int. 2004 Oct;45(5):783. |
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more information: | company product webpage |