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| Catalog Code: | NB100-79862 |
| Product Name: | FIP1 Antibody |
| Product Description: | Rabbit Polyclonal anti-FIP1 |
| Clonality: | Polyclonal |
| ListPrice: | 375 |
| Gene ID: | 81608 |
| Reference Sequence: | NP_112179.2 |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 544 and 594 of human factor interacting with PAP using the numbering given in entry NP_112179.2 (GeneID 81608). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry on paraffin sections. Epitope exposure with citrate bufferexposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated. |
| Background: | FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3'-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity. Alternate names for FIP1 include pre-mRNA 3'-end processing factor FIP1, FIP1-like 1, hFip1, and RHE. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | Immunohistochemistry-Paraffin 1:100-1:500 |
| Species Summary: | Hu |
| Alternate Names: | anti-FIP1 antibody, anti-FIP-1 antibody, anti-FIP1L1 antibody, anti-factor interacting with PAP antibody, anti-RHE antibody, anti-rearranged in hypereosinophilia antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |