| CatalogCode: | NB100-78619 |
| ProductName: | TGFBR2 Antibody |
| Product Description: | Rabbit Polyclonal anti-TGFBR2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to a region of Human TGFBR2 |
| CrossReactivity: | Human. |
| Packaging: | 0.1 mg of protein A purified Rabbit antisera |
| Uses: | For WB: use at a concentration of 5.0 µg/ml in 5% skim milk/PBS buffer. |
| Localization: | Type 1 membrane protein |
| Control: | HepG2 cell lysate |
| Background: | Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF-beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of beta glycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta- RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate-buffered saline containing 2% sucrose |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TGF beta Receptor II antibody, anti-AAT 3 antibody, anti-AAT3 antibody, anti-FAA 3 antibody, anti-FAA3 antibody, anti-HNPCC6 antibody, anti-MFS 2 antibody, anti-MFS2 antibody, anti-RIIC antibody, anti-TAAD 2 antibody, anti-TAAD2 antibody, anti-TbetaR II antibody, anti-TGF beta receptor type 2 antibody, anti-TGF beta receptor type II antibody, anti-TGF beta type II receptor antibody, anti-TGFB R2 antibody, anti-TGFbeta RII antibody, anti-TGFBR 2 antibody, anti-TGFR 2 antibody, anti-TGFR2 antibody, anti-Transforming growth factor beta receptor II antibody, anti-Transforming growth factor beta receptor type II antibody |
| ProteinTarget: | TGFBR2 |
| PackageSize: | 0.1 mg |
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