| Catalog Code: | NB100-78591 |
| Product Type: | Primary Antibody |
| Product Name: | CBL Antibody |
| List Price: | 285 |
| Clonality: | Polyclonal |
| Gene ID: | 867 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-CBL |
| Cross Reactivity: | Human. |
| Species Summary: | Hu(+) |
| Background: | The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL's interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav. |
| Alternate Names: | anti-C CBL antibody, anti-Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody, anti-Casitas B lineage lymphoma proto oncogene antibody, anti-CBL 2 antibody # CBL2 antibody, anti-E3 ubiquitin protein ligase CBL antibody, anti-Oncogene CBL2 antibody, anti-Proto oncogene c CBL antibody, anti-RING finger protein 55 antibody, anti-RNF55 antibody, anti-Signal transduction protein CBL antibody |
| Immunogen: | Synthetic peptide - Containing amino acids between 850-1000. |
| Localization: | Nuclear |
| Purity: | protein A purified |
| Buffer: | Phosphate-buffered saline, pH 7.2 |
| Preservative: | 0.01% thimerosal |
| Packaging: | 0.1 mg of protein A purified Rabbit antisera |
| PackageSize: | 0.1 mg |
| Concentration: | 1 mg/ml |
| Uses: | Suggested starting dilutions are as follows. WB: 1:2,000-1:10,000. |
| Application Summary: | Western Blot 1:2, 000-1:10, 000 |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| WebLink: | www.novusbio.com/data_sheet/index/NB100 ... |