| Catalog Code: | NB100-78571 |
| Product Type: | Primary Antibody |
| Product Name: | p90 Rsk Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 6195 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-p90 Rsk [Thr368/Ser372] |
| Phosphorylated: | Thr368/Ser372 |
| Cross Reactivity: | Human. |
| Species Summary: | Hu(+) |
| Background: | p90 Rsk (ribosomal protein S6 kinase) is a 90 serine/threonine kinase and contains two protein kinase domains in a single polypeptide. The N-terminal kinase domain is necessary for the phosphorylation of peptide substrates, whereas the C-terminal kinase domain is required for full activation of the N-terminal domain.This kinase is normally cytosolic but is transiently targeted to the membrane after activation. p90 Rsk phosphorylates a range of substrates including ribosomal protein S6 and is activated by the extracellular signal kinases ERK 1/2, PDK-1,and MAPK kinase cascade. p90 Rsk is phosphorylated and can interact with 14-3-3 beta, and ERK 1/2 under quiescent conditions p90 Rsk is decreased upon mitogen stimulation. The Poly6370 antibody recognizes human phospho-p90 Rsk(Thr368/Ser372) and has been shown to be useful for immunofluorence staining. |
| Alternate Names: | anti-B7-1 antibody, anti-B7 antibody, anti-Ly-53 antibody |
| Immunogen: | Recombinant (partial), N-terminal |
| Purity: | Immunogen affinity purified |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera |
| PackageSize: | 0.1 ml |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. |
| Application Summary: | immunofluorescence |
| Storage: | Store at 4C. Do not freeze. |
| General References: | 1. Chrestensen, C., et al., 2002. J. Biol. Chem. 277:27733. 2. Moller, D., et al., 1994. Am. J. Physiol. 266, C351. 3. Franklin, R., et al., 1995. J. Immunol. 154:4965. 4. Cavet, M., et al., 2003. J. Biol. Chem. 278:18376. |
| WebLink: | www.novusbio.com/data_sheet/index/NB100 ... |