| CatalogCode: | NB100-78570 |
| ProductName: | Presenilin Antibody |
| Product Description: | Rabbit Polyclonal anti-Presenilin |
| Clonality: | Polyclonal |
| Immunogen: | Modified peptide |
| CrossReactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. |
| Control: | Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph |
| Background: | Presenilin 1 belongs to the peptidase A22A family. Predicted molecular weight approximately 53 kD. Presenilins assemble with nicastrin, PEN-2, and APH-1 into an active g-secretase complex responsible for proteolytic cleavage of amyloid precursor protein (APP) and transmembrane cleavage of Notch receptor proteins. Presenilin 1 is subjected to an endoproteolytic cleavage, generating a stable heterodimer composed of an N-terminal and a C-terminal fragment. Presenilin 1 may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane and involved in stimulates cell-cell adhesion, negatively regulating Wnt signaling, and hematopoiesis. Presenilin1 residues Ser353 and Ser357 are phosphorylated by GSK-3 beta. nbspThe Poly6366 antibody recognizes human phospho-Presenilin 1 (Ser353/Ser357) and has been shown to be useful for immunoflorence staining. This antibody does not detect Presenilin 1 phosphorylated at other sites. nbsp |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 325 |
| AppSummary: | IF |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Presenilin 1 antibody, anti-PS-1 antibody, anti-Protein S182 antibody |
| ProteinTarget: | Presenilin |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Laudon, H., et al. 2005. J. Biol. Chem. 280: 35352 2. De Strooper, B. 2003. Neuron 38: 9 3. Kirschenbaum F., et al. 2001. J. Biol. Chem. 276:7366 |