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| Catalog Code: | NB100-78568 |
| Product Name: | CRIK Antibody |
| Product Description: | Rabbit Polyclonal anti-CRIK |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Peptide-KLH, C-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. |
| Background: | CRIK (Citron Rho-interacting kinase) is a serine/threonine kinase belonging to the myotonic dystrophy kinase family. This kinase contains an AGC-kinase C-terminal domain, CNH domain, PH domain, phorbol-ester/DAG-type zinc finger, and a protein kinase domain. Citron kinase can be produced in at least two different isoforms: Citron Rho-interacting kinase (CRIK) and CRIK-short kinase (SK). CRIK is a 231 kD protein in which the kinase domain is followed by the sequence of Citron, a previously identified Rho/Rac binding protein. SK is a ~54 kD protein which consists mostly of the kinase domain. Citron kinase binds to Rho-GTP and has been shown to be involved in the regulation of cytokinesis, control of G2/M transition in the hepatocyte cell cycle, and the development of the central nervous system. The Poly6364 antibody recognizes human CRIK and has been shown to be useful for immunoflorence staining. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | immunofluorescence |
| Species Summary: | Hu |
| Alternate Names: | anti-CRIK antibody, anti-STK21 antibody, anti-Rho-interacting serine/threonine kinase antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Madaule P., et al. 2000. Microsc Res Tech. 49:123 2. Di Cunto F., et al. 2000. Neuron 28:115 3. Di Cunto F., et al. 1998. J Biol Chem. 273:29706 |
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