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| Catalog Code: | NB100-78564 |
| Product Name: | TSC2 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-TSC2 Phosphospecific [Ser664] |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Modified peptide |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. |
| Background: | Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664. The Poly6359 antibody recognizes human phospho-TSC2 (Ser664) and has been shown to be useful for immunoflorence staining. This antibody does not detect TSC2 phosphorylated at other sites. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2 with 50% glycerol. |
| Application Summary: | immunofluorescence |
| Species Summary: | Hu |
| Alternate Names: | anti-Tuberin antibody, anti-Tuberous sclerosis 2 protein antibody, anti-TSC4 antibody |
| Package Size: | 0.1 mg |
| Preservative: | Sodium Azide |
| Phosphorylated: | Ser664 |
| General References: | 1. Inoki K., et al. 2002. Nat. Cell Biol. 4: 648 2. Manning BD., et al. 2002. Mol. Cell 1:151 3. Ma L., et al. 2005. Cell 121:179 |
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