| Catalog Code: | NB100-78562 |
| Product Type: | Primary Antibody |
| Product Name: | ATIC Antibody |
| List Price: | 285 |
| Clonality: | Monoclonal |
| Gene ID: | 471 |
| Host: | Mouse |
| Clone: | F38P7H9 |
| Isotype: | IgG1, kappa |
| Product Description: | Mouse Monoclonal anti-ATIC (F38P7H9) |
| Cross Reactivity: | Human, Mouse, Rat, Frog, and Fruit fly. |
| Species Summary: | Hu(+),Mu(+),Rt(+),Xp(+),Dr(+) |
| Background: | ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, frog and fruit fly ATIC. |
| Alternate Names: | anti-IL-10R antibody, anti-Interleukin-10 Receptor antibody |
| Immunogen: | Ovalbumin-conjugated synthetic Peptide AHTNLRLFHH |
| Purity: | Immunogen affinity purified |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| PackageSize: | 0.1 mg |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-10 mug per 5 ml antibody dilution buffer for each mini-gel. nbsp It is recommended that the reagent be titrated for optimal performance for each application. |
| Application Summary: | immunohistochemistry, Western Blot |
| Storage: | Store at 4C. Do not freeze. |
| General References: | 1. Rayl, E. A., et al. 1996. J. Biol. Chem. 271: 2225 2. Sugita T., et al. 1997. J. Biochem. 122: 309 3. Marie, S., et al. 2004. Am. J. Hum. Genet. 74: 1276 |
| WebLink: | www.novusbio.com/data_sheet/index/NB100 ... |