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| Catalog Code: | NB100-78560 |
| Product Name: | TIMP-2 Antibody |
| Product Description: | Mouse Monoclonal anti-TIMP-2 (F27P3A4) |
| Clone: | F27P3A4 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Ovalbumin-conjugated synthetic Peptide DSGNDIYGNPI |
| Cross Reactivity: | Human, Mouse, Rabbit, Chicken, Zebrafish, Pig. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-10 mug per 5 ml antibody dilution buffer for each mini-gel. nbsp It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | TIMP-2 (Tissue inhibitor of metalloproteinase 2) is a nonglycosylated protein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 24 kD. The mechanisms of TIMPs inhibit angiogenesis appear to be specific for each member of the TIMP family. TIMP-2 binds to the surface of human endothelial cells through interaction with the integrin alpha3 beta1, and abrogates angiogenic factor induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. Clone F27P3A4 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human, mouse, rabbit, chicken, zebrafish, and pig TIMP-2. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2 |
| Application Summary: | ELISA, immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, Rb, Ch, Ze, Po |
| Alternate Names: | anti-Metalloproteinase inhibitor 2 antibody, anti-Tissue inhibitor of metalloproteinases 2; TIMP2 antibody |
| Package Size: | 0.1 mg |
| Preservative: | Sodium Azide |
| General References: | 1. Stetler-Stevenson., et al. 1989. J. Biol. Chem. 264: 17374 2. Hammani, K., et al. 1996. J. Biol. Chem. 271: 25498 3. Seo, D.-W., et al. 2003. Cell 114: 171 |
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