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| Catalog Code: | NB100-78559 |
| Product Name: | TIMP-1 Antibody |
| Product Description: | Mouse Monoclonal anti-TIMP-1 (F31P2A5) |
| Clone: | F31P2A5 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Ovalbumin-conjugated synthetic Peptide FQALGDAADIR |
| Cross Reactivity: | Human, Monkey. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-10 mug per 5 ml antibody dilution buffer for each mini-gel. Immunohistochemistry-paraffin. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD. TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels TIMP-1 protein has been found in several types of cancers including breast cancer and this increase associated with a poor patient prognosis. TIMP-1 has also been implicated in the inhibition of apoptosis, promotion of growth, and process of angiogenesis. TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). Clone F31P2A5 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human and monkey TIMP-1. nbsp |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| Application Summary: | ELISA , Western Blot , Immunohistochemistry-Paraffin |
| Species Summary: | Hu, Mk |
| Alternate Names: | anti-TIMP1 antibody, anti-EPA antibody, anti-Collagenase inhibitor antibody, anti-Fibroblast collagenase inhibitor antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Lambert, E., et al. 2004. Crit. Rev. Oncol./Hematol. 49: 187 2. Schrohl, A. S., et al. 2004. Clin. Cancer Res. 10: 2289 3. Li, G., et al. 1999. Cancer Res. 59: 6267 |
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