| CatalogCode: | NB100-78554 |
| ProductName: | MMP2 Antibody |
| Product Description: | Mouse Monoclonal anti-MMP2 (F14P4D3) |
| Clone: | F14P4D3 |
| Clonality: | Monoclonal |
| Immunogen: | Ovalbumin-conjugated synthetic peptide TSLGLPPDVQRVD |
| CrossReactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 mug antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Extracellular, plasma membrane |
| Background: | Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP2 is a metalloproteinase that specifically cleaves type IV collagen, the major structural component of basement membranes. MMP2 is thought to contribute to the invasion and metastasis of various human malignancies. Clone F14P4D3 has been shown to be useful for western blotting, ELISA and immunohistochemistry of human MMP2. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host_Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| ListPrice: | 285 |
| AppSummary: | ELISA, IHC, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CLG4 antibody, anti-CLG4A antibody, anti-Gelatinase A antibody, anti-72 kDa type IV collagenase precursor antibody, anti-TBE-1 antibody, anti-MMP-2 antibody |
| ProteinTarget: | MMP2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Collier, I. E., et al. 1992. Genomics 9: 429 2. Martignetti, J. A., et al. 2001. Nature Genet. 28: 261 3. Chaussain-Miller C., et al. 2006. J Dent Res 85:22 |
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