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| Catalog Code: | NB100-78548 |
| Product Name: | Caspase-2L Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase-2L |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Peptide mapping to the carboxy terminal of human caspase-2L. |
| Cross Reactivity: | Human, Mouse, Rat. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. nbsp Western blotting suggested working dilution(s): Use 25 microliter per 5 ml antibody dilution buffer for each mini-gel. Immunohistochemistry-paraffin. It is recommended that the reagent be titrated for optimal performance for each application. nbsp |
| Background: | Caspase 2 (Nedd-2/ICH-1) is a member of the peptidase family C14 that contains a CARD domain. This caspase has been reported to have two isoforms. The larger protein, Caspase-2L(ICH-1L) possesses proapoptotic activities , whereas Caspase-2S (ICH-1S) is able to inhibit apoptosis. When cells are induced to undergo apoptosis, endogenous Caspase 2 is probably activated early in the apoptotic process by cleaves into three fragments of 33 and 14 kD, and then these are further processed into 18 and 12 kDa active subunits. The Poly6340 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of nbsp human, mouse, and rat caspase-2L p12 subunit and precursor (also designated Ich-1L). |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | immunoprecipitation , Western Blot , Immunohistochemistry-Paraffin |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-ICH-1L antibody, anti-CASP2L antibody |
| Package Size: | 0.5 ml |
| General References: | 1. Wang L., et al. 1994. Cell 78: 739 2. Li H., et al. 996. J. Biol. Chem. 272: 21010 3. Tinel, A., et al. 2004. Science 304: 843 |
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