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| Catalog Code: | NB100-78541 |
| Product Name: | Cdk4 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cdk4 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Peptide mapping to the carboxy terminus of mouse Cdk4 |
| Cross Reactivity: | Human, Mouse, Rat. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. nbsp Western blotting suggested working dilution(s): Use 25 microliter per 5 ml antibody dilution buffer for each mini-gel. nbsp Immunohistochemistry. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Cdk4 (Cyclin dependent kinase 4) belongs to the Ser/Thr protein kinase superfamily, CDC2/CDKX subfamily, and predicted molecular weight 34 kD. The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase. D-type cyclins are induced by mitogens and activated Cdk4/cyclin D complexes are thought to phosphorylate the retinoblastoma susceptibility protein (Rb), thereby facilitating G, progression. The Poly6333 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Cdk4 protein. |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-Cell division kinase 4 antibody |
| Package Size: | 0.5 ml |
| General References: | 1. Sherr, C.J., et al. 1994. Cell 75: 551 2. Weinberg, R.A., et al. 1995. Cell 81: 323 3. Harbour, J., et al. 1999. Cell 98: 859 |
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