| CatalogCode: | NB100-78538 |
| ProductName: | Cbl Antibody |
| Product Description: | Rabbit Polyclonal anti-Cbl |
| Clonality: | Polyclonal |
| Immunogen: | peptide mapping to the carboxy terminal domain of human Cbl |
| CrossReactivity: | Human, Mouse, Rat. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. nbsp Western blotting suggested working dilution(s): Use 25 microliter per 5 ml antibody dilution buffer for each mini-gel. nbsp It is recommended that the reagent be titrated for optimal performance for each application. nbsp |
| Control: | Ubiquitous cytoplasmic protein, predicted molecular weight 120 kD. |
| Background: | The proto-oncogene c-Cbl was initially identified as the cellular homologue of v-Cbl oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. The Cbl family comprises three mammalian proteins, c-Cbl, Cbl-b, and Cbl-3; among these, c-Cbl and Cbl-b are expressed in hemopoietic cells, whereas Cbl-3 is expressed only in epithelial tissues. Cbl proteins can function as E3 ubiquitin (Ub) ligases, and in more recent studies Cbl has been implicated in the negative regulation of various RTKs. The poly6330 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Cbl protein. |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-E3 ubiquitin-protein ligase Cbl antibody, anti-Proto-oncogene c-Cbl antibody |
| ProteinTarget: | Cbl |
| PackageSize: | 0.5 ml |
| GeneralRef: | 1. Liu YC., et al. 1998. Cell Signal 10:377. 2. Gu, H., et al. 2002. Nature Immun. 3: 1192. 3. Joazeiro, C. A. P., et al. 1999. Science 286: 309. |
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