| CatalogCode: | NB100-78536 |
| ProductName: | RAR alpha Antibody |
| Product Description: | Rabbit Polyclonal anti-RAR alpha [Ser369] |
| Clonality: | Polyclonal |
| Immunogen: | Modified peptide |
| CrossReactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Nuclear |
| Background: | RAR alpha (retinoic acid receptor alpha) is a 51 kD member of the nuclear hormone receptor family, NR1 subfamily. This nuclear protein contains modulating, DNA-binding, and steroid binding domains, and has been reported to have multiple isoforms. RAR alpha is a nuclear receptor for retinoic acid that controls cell function by regulating gene expression and inducing profound effects on vertebrate development, acting as a morphogen and powerful teratogen. RAR alpha is increased by protein kinase C stimulation, and estrogen; decreased at G0/G1 to S phase of cell cycle and in lymphocytes by cellular activation. RAR alpha can be modified by phosphorylation and has been shown to interact with NCOA3 and NCOA6 co-activators leading to strong increases in the transcription of target genes. The Poly6328 antibody recognizes human RAR alpha and has been shown to be useful for immunofluorescence microscopy. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 325 |
| AppSummary: | IF |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Retinoic acid receptor alpha antibody, anti-RAR alpha antibody, anti-RAR alpha antibody, anti-RAR-alpha antibody |
| ProteinTarget: | RAR alpha |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Giguere, V., et al., 1987. Nature 330:624. 2. Petkovich, M., et al., 1987. Nature 330:444. |
| Phosphorylated: | Ser369 |